Genetic analyses reveal a role for vitamin D insufficiency in HCV-associated hepatocellular carcinoma development.

doi:10.1371/journal.pone.0064053

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Article

Genetic analyses reveal a role for vitamin D insufficiency in HCV-associated hepatocellular carcinoma development.

PloS one - 1 Jan 2013

Lange Christian M, Miki Daiki, Ochi Hidenori, Nischalke Hans-Dieter, Bojunga Jörg, Bibert Stéphanie, Morikawa Kenichi, Gouttenoire Jérôme, Cerny Andreas, Dufour Jean-François, Gorgievski-Hrisoho Meri, Heim Markus H, Malinverni Raffaele, Müllhaupt Beat, Negro Francesco, Semela David, Kutalik Zoltan, Müller Tobias, Spengler Ulrich, Berg Thomas, Chayama Kazuaki, Moradpour Darius, Bochud Pierre-Yves

Abstract excerpt

BACKGROUND: Vitamin D insufficiency has been associated with the occurrence of various types of cancer, but causal relationships remain elusive. We therefore aimed to determine the relationship between genetic determinants of vitamin D serum levels and the risk of developing hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC). METHODOLOGY/PRINCIPAL FINDINGS: Associations between CYP2R1, GC, and DHCR7...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23734184
DOI: 10.1371/journal.pone.0064053
PMCID: PMC3667029

Genes

DHCR7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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