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Article

Discovery of novel allosteric effectors based on the predicted allosteric sites for Escherichia coli D-3-phosphoglycerate dehydrogenase.

PloS one - 1 Jan 2014

Wang Qian, Qi Yifei, Yin Ning, Lai Luhua

Abstract excerpt

D-3-phosphoglycerate dehydrogenase (PGDH) from Escherichia coli catalyzes the first critical step in serine biosynthesis, and can be allosterically inhibited by serine. In a previous study, we developed a computational method for allosteric site prediction using a coarse-grained two-state Gō Model and perturbation. Two potential allosteric sites were predicted for E. coli PGDH, one close to the active site and...

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PMID: 24733054
DOI: 10.1371/journal.pone.0094829
PMCID: PMC3986399

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