Metabolic rewiring drives resistance to targeted cancer therapy

Abstract excerpt

Mol Syst Biol. 8: 597 Cancers are diseases of uncontrolled cell growth in which cells acquire mutations that allow for proliferation outside the context of normal tissue development. The genetic events that define tumorigenesis have been, to a large extent, cataloged (Stratton et al , 2009; Beroukhim et al , 2010). Therapies have been developed that interfere with these defined genetic aberrations (Slamon et al...

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