Article

Engineered collagen-targeting therapeutics reverse lung and kidney fibrosis in mice

2022-01-05

Abstract excerpt

Fibrotic diseases are involved in 45% of deaths in the United States. In particular, fibrosis of the kidney and lung are major public health concerns due to their high prevalence and lack of existing treatment options. Here, we harness the pathophysiological features of fibrotic diseases, namely leaky vasculature and aberrant extracellular matrix (ECM) protein deposition (i.e. collagen), to target an anti-fibrotic...

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Literature Corpus work: e96c59bd-3c60-5d74-a9f5-9abed212b3ab
DOI: 10.1101/2022.01.04.474747

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