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Article

Progranulin genetic screening in frontotemporal lobar degeneration patients from central Italy.

Cellular and molecular neurobiology - 1 Jan 2012

Bagnoli Silvia, Piaceri Irene, Tedde Andrea, Piacentini Silvia, Nannucci Serena, Bracco Laura, Sorbi Sandro, Nacmias Benedetta

Abstract excerpt

Recently, mutations in the progranulin gene (GRN) were reported to account for the vast majority of Frontotemporal lobar Degeneration (FTLD) and a growing number of reports describe the implication of this gene in the development of the FTLD pathology with a significant variation in clinical features. To better clarify the contribution of GRN mutations to Italian FTLD, we screened 381 subjects: 171 cases and 210...

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Identifiers

PMID: 21800185
DOI: 10.1007/s10571-011-9741-y

Genes

GRN

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