Article
The Uppsala APP Mutation Promotes Wild-Type Amyloid-β Aggregation and Deposition In Vivo.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Jun 2026
Ge Junyue, Pagnon de la Vega María, Zampar Silvia, Cerilli Enrica, Koutarapu Srinivas, Wu Ling, Fraser Paul, Arkan Sertan, Giedraitis Vilmantas, Lannfelt Lars, Hultqvist Greta, Syvänen Stina, Ingelsson Martin, Hanrieder Jörg, Sehlin Dag
Abstract excerpt
Amyloid-β (Aβ) is widely regarded as a key initiator of theneurodegenerative cascade in Alzheimer's disease (AD).Studies of pathogenic mutations in the amyloid precursor protein (APP) genehave greatly advanced understanding of Aβ biochemistry, aggregation, anddeposition. One such mutation, Uppsala APP (APPUpp), produces AβUpp42Δ19-24, whichis highly aggregation-prone due to a six-amino-acid deletion in its...
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