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Article

Hypoxia Changes the Expression of the Epidermal Growth Factor (EGF) System in Human Hearts and Cultured Cardiomyocytes

5 Jul 2012

Abstract excerpt

BACKGROUND: The epidermal growth factor (EGF) receptors HER2 and HER4 and the ligands HB-EGF and NRG1 are crucial for heart development. The purpose of our study was to investigate the role of the complete EGF system in relation to hypoxia of the heart. METHODOLOGY/PRINCIPAL FINDINGS: We examined the mRNA expression by real time PCR of the 4 receptors and 12 ligands from the EGF-system in paired normoxic and...

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PMID: 22792252
DOI: 10.1371/journal.pone.0040243

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