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Article

ErbB2 promotes endothelial phenotype of human left ventricular epicardial highly proliferative cells (eHiPC).

Journal of molecular and cellular cardiology - 1 Feb 2018

Ryzhov Sergey, Robich Michael P, Roberts Daniel J, Favreau-Lessard Amanda J, Peterson Sarah M, Jachimowicz Edward, Rath Rutwik, Vary Calvin P H, Quinn Reed, Kramer Robert S, Sawyer Douglas B

Abstract excerpt

The adult human heart contains a subpopulation of highly proliferative cells. The role of ErbB receptors in these cells has not been studied. From human left ventricular (LV) epicardial biopsies, we isolated highly proliferative cells (eHiPC) to characterize the cell surface expression and function of ErbB receptors in the regulation of cell proliferation and phenotype. We found that human LV eHiPC express all...

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Identifiers

PMID: 29291395
DOI: 10.1016/j.yjmcc.2017.12.013
PMCID: PMC5926239

Genes

EGF

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