Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping functional interactions in a heterodimeric phospholipid pump.

The Journal of biological chemistry - 31 Aug 2012

Puts Catheleyne F, Panatala Radhakrishnan, Hennrich Hanka, Tsareva Alina, Williamson Patrick, Holthuis Joost C M

Abstract excerpt

Type 4 P-type ATPases (P(4)-ATPases) catalyze phospholipid transport to generate phospholipid asymmetry across membranes of late secretory and endocytic compartments, but their kinship to cation-transporting P-type transporters raised doubts about whether P(4)-ATPases alone are sufficient to mediate flippase activity. P(4)-ATPases form heteromeric complexes with Cdc50 proteins. Studies of the enzymatic properties...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Biological Transport, Active

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multiprotein Complexes

Share to Peptide Mapping

Share to Phospholipid Transfer Proteins

Share to Protein Multimerization

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22791719
DOI: 10.1074/jbc.M112.371088
PMCID: PMC3436301

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping functional interactions in a heterodimeric phospholipid pump.PMID 22791719Read ↗

Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases.Semantic proximity Read ↗

Role of post-translational modifications at the β-subunit ectodomain in complex association with a promiscuous plant P4-ATPase.Semantic proximity Read ↗

Structural Determinants for the Monomeric and Phospholipid-Transport P4B-ATPase via comprehensive <i>in silico</i> analysis of P4-ATPase structuresSemantic proximity Read ↗

Specific mutations in mammalian P4-ATPase ATP8A2 catalytic subunit entail differential glycosylation of the accessory CDC50A subunit.Semantic proximity Read ↗

Critical role of a transmembrane lysine in aminophospholipid transport by mammalian photoreceptor P4-ATPase ATP8A2.Semantic proximity Read ↗

Crystal structure of a human plasma membrane phospholipid flippaseSemantic proximity Read ↗

Isolation and characterization of novel mutations in CDC50, the non-catalytic subunit of the Drs2p phospholipid flippase.Semantic proximity Read ↗

Mammalian P4-ATPases and ABC transporters and their role in phospholipid transport.Semantic proximity Read ↗

Identification and characterization of yeast and human glycosphingolipid flippasesSemantic proximity Read ↗

High phosphatidylinositol 4-phosphate (PI4P)-dependent ATPase activity for the Drs2p-Cdc50p flippase after removal of its N- and C-terminal extensions.Semantic proximity Read ↗

Two-gate mechanism for phospholipid selection and transport by type IV P-type ATPases.Semantic proximity Read ↗

Role for phospholipid flippase complex of ATP8A1 and CDC50A proteins in cell migration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.