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Article

Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases.

The Journal of biological chemistry - 17 Dec 2010

van der Velden Lieke M, Wichers Catharina G K, van Breevoort Adriana E D, Coleman Jonathan A, Molday Robert S, Berger Ruud, Klomp Leo W J, van de Graaf Stan F J

Abstract excerpt

Members of the P(4) family of P-type ATPases (P(4)-ATPases) are believed to function as phospholipid flippases in complex with CDC50 proteins. Mutations in the human class 1 P(4)-ATPase gene ATP8B1 cause a severe syndrome characterized by impaired bile flow (intrahepatic cholestasis), often leading to end-stage liver failure in childhood. In this study, we determined the specificity of human class 1 P(4)-ATPase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20947505
DOI: 10.1074/jbc.M110.139006
PMCID: PMC3000991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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