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Article

C3 glomerulonephritis associated with a missense mutation in the factor H gene.

The Tohoku journal of experimental medicine - 1 Jul 2012

Sugimoto Keisuke, Fujita Shinsuke, Miyazaki Kouhei, Okada Mitsuru, Takemura Tsukasa

Abstract excerpt

The complement system, the major component of the innate immune functions resisting microbial infection, includes the classical complement pathway, the alternate pathway, and the mannose-binding lectin pathway. All of these merge at the level of complement component (C) 3. Complement factor H (CFH), a soluble complement mediator in blood, regulates alternate pathway activation; a conformational change of C3...

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Identifiers

PMID: 22790979
DOI: 10.1620/tjem.227.211

Genes

CFH

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