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Article

Secondary focal and segmental glomerulosclerosis associated with single-nucleotide polymorphisms in the genes encoding complement factor H and C3.

American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 Aug 2012

Sethi Sanjeev, Fervenza Fernando C, Zhang Yuzhou, Smith Richard J H

Abstract excerpt

Genetic causes of focal and segmental glomerulosclerosis (FSGS) typically involve mutations and allele variants of genes expressed in podocytes or, more rarely, glomerular basement membranes. In this report, we describe a 60-year-old woman with chronic kidney disease whose kidney biopsy showed FSGS. Immunoglobulins and C3 were undetectable in immunofluorescence studies. Electron microscopy showed subendothelial...

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Share to Complement C3
Share to Complement Factor H

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complement Pathway, Alternative

Share to CFH gene

Share to Glomerulosclerosis, Focal Segmental

Share to Polymorphism, Single Nucleotide

Share to Sequence Analysis, Protein

Source

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Identifiers

PMID: 22594991
DOI: 10.1053/j.ajkd.2012.04.011
PMCID: PMC4433495

Genes

CFH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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