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Article

Cofilin overexpression affects actin cytoskeleton organization and migration of human colon adenocarcinoma cells.

Histochemistry and cell biology - 1 Nov 2012

Popow-Woźniak Agnieszka, Mazur Antonina Joanna, Mannherz Hans Georg, Malicka-Błaszkiewicz Maria, Nowak Dorota

Abstract excerpt

The dynamic reorganization of actin cytoskeleton is regulated by a large number of actin-binding proteins. Among them, the interaction of ADF/cofilin with monomeric and filamentous actin is very important, since it severs actin filaments. It also positively influences actin treadmilling. The activity of ADF/cofilin is reversibly regulated by phosphorylation and dephosphorylation at Ser-3, with the phosphorylated...

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Identifiers

PMID: 22790341
DOI: 10.1007/s00418-012-0988-2
PMCID: PMC3470684

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