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Article

Coordinated effects of microRNA-494 induce G₂/M arrest in human cholangiocarcinoma

15 Jan 2012

Abstract excerpt

MicroRNA (miRs) have emerged as salient regulators in cancer homeostasis and, recently, as putative therapeutics. Cholangiocarcinomas (CCA) are aggressive cancers with survival usually measured in months. mRNA arrays followed by pathway analysis revealed that miR-494 is a major modulator of the cell cycle progression from gap 2 (G₂) to mitosis (M). We performed fluorescence activated cell sorting (FACS) as well...

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PMID: 22785131
DOI: 10.4161/cc.21105

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