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Article

The protein kinase CK2 contributes to the malignant phenotype of cholangiocarcinoma cells

22 Oct 2019

Abstract excerpt

Cholangiocarcinoma (CCA) is a particularly aggressive hepatobiliary malignancy, for which the molecular mechanisms underlying the malignant phenotype are still poorly understood, and novel and effective therapeutic strategies are limited. The pro-survival protein kinase CK2 is frequently overexpressed in cancer and is receiving increasing interest as an anti-tumor drug target. Its precise role in CCA biology is...

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PMID: 31641101
DOI: 10.1038/s41389-019-0171-x

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