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Article

MicroRNA-188 suppresses G1/S transition by targeting multiple cyclin/CDK complexes

10 Oct 2014

Abstract excerpt

BACKGROUND: Accelerated cell cycle progression is the common feature of most cancers. MiRNAs can act as oncogenes or tumor suppressors by directly modulating cell cycle machinery. It has been shown that miR-188 is upregulated in UVB-irradiated mouse skin and human nasopharyngeal carcinoma CNE cells under hypoxic stress. However, little is known about the function of miR-188 in cell proliferation and growth...

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PMID: 25304455
DOI: 10.1186/s12964-014-0066-6

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