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Biomarker Changes during 20 Years Preceding Alzheimer’s Disease

21 Feb 2024

Abstract excerpt

Background Biomarker changes that occur in the period between normal cognition and the diagnosis of sporadic Alzheimer’s disease have not been extensively investigated in longitudinal studies. Methods We conducted a multicenter, nested case–control study of Alzheimer’s disease biomarkers in cognitively normal participants who were enrolled in the China Cognition and Aging Study from January 2000 through December...

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PMID: 38381674
DOI: 10.1056/nejmoa2310168

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