Enhanced induction of epidermal ornithine decarboxylase activity in C57BL/6 compared to DBA/2 mice by protein kinase C-activating skin tumor promoters: relevance to genetically mediated differences in promotion susceptibility.

doi:10.1093/carcin/13.2.177

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Article

Enhanced induction of epidermal ornithine decarboxylase activity in C57BL/6 compared to DBA/2 mice by protein kinase C-activating skin tumor promoters: relevance to genetically mediated differences in promotion susceptibility.

Carcinogenesis - 1 Feb 1992

Imamoto A, Beltrán L M, Fujiki H, Chenicek K J, DiGiovanni J

Abstract excerpt

Previous work from our laboratory demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) or a synthetic diacylglycerol induced significantly higher epidermal ornithine decarboxylase (ODC) activity in C57BL/6 than in DBA/2 mice. To understand further the genetic basis for this strain differe...

Topics

Animals
Anthracenes
Carcinogens
Cluster Analysis
Disease Susceptibility
Enzyme Activation
Female
Genetic Predisposition to Disease
Lyngbya Toxins
Mice
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred DBA

Mice, Mutant Strains

Ornithine Decarboxylase

Protein Kinase C

Skin

Skin Neoplasms

Tetradecanoylphorbol Acetate

Source

Open in PubMed

Identifiers

PMID: 1740006
DOI: 10.1093/carcin/13.2.177

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1740006-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Enhanced induction of epidermal ornithine decarboxylase activity in C57BL/6 compared to DBA/2 mice by protein kinase C-activating skin tumor promoters: relevance to genetically mediated differences in promotion susceptibility.PMID 1740006Read ↗

Identification of an X-linked locus modifying mouse skin tumor susceptibility.Semantic proximity Read ↗

Identification of novel genetic loci contributing to 12-O-tetradecanoylphorbol-13-acetate skin tumor promotion susceptibility in DBA/2 and C57BL/6 mice.Semantic proximity Read ↗

Overexpression of a dominant-negative ornithine decarboxylase in mouse skin: effect on enzyme activity and papilloma formation.Semantic proximity Read ↗

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