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Article

Zebrafish Cxcr4a determines the proliferative response to Hedgehog signalling.

Development (Cambridge, England) - 1 Aug 2012

Stückemann Tom, Wegleiter Thomas, Stefan Eduard, Nägele Olivier, Tarbashevich Katsiaryna, Böck Günther, Raz Erez, Aanstad Pia

Abstract excerpt

The Hedgehog (Hh) pathway plays dual roles in proliferation and patterning during embryonic development, but the mechanism(s) that distinguish the mitogenic and patterning activities of Hh signalling are not fully understood. An additional level of complexity is provided by the observation that Hh signalling can both promote and inhibit cell proliferation. One model to account for this apparent paradox is that Hh...

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PMID: 22782722
DOI: 10.1242/dev.074930

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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