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Article

Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity.

Proceedings of the National Academy of Sciences of the United States of America - 24 Jul 2012

Liu Jing, Guo Ming, Zhang Di, Cheng Shao-Ying, Liu Meilian, Ding Jun, Scherer Philipp E, Liu Feng, Lu Xin-Yun

Abstract excerpt

Depression is a debilitating mental illness and is often comorbid with metabolic disorders such as type 2 diabetes. Adiponectin is an adipocyte-derived hormone with antidiabetic and insulin-sensitizing properties. Here we show that adiponectin levels in plasma are reduced in a chronic social-defeat stress model of depression, which correlates with decreased social interaction time. A reduction in adiponectin...

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Identifiers

PMID: 22778410
DOI: 10.1073/pnas.1202835109
PMCID: PMC3409774

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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