Article

A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug Resistance

2025-06-16

Abstract excerpt

SHP2 is a phosphatase and a critical mediator of receptor tyrosine kinase (RTK)-driven RAS/mitogen-activated protein kinase (MAPK) signaling. Despite promising preclinical data, SHP2 inhibitors have shown minimal clinical efficacy, with no defined clinical mechanisms of primary resistance. Here, we elucidate phosphorylation of SHP2 at tyrosine 62 (pY62) as a hotspot phosphorylation site in the proteome and RTK-dri...

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Literature Corpus work: 764c76ac-354a-54d6-8153-b11f58af5927
DOI: 10.1101/2025.06.11.659120

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