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Article

β-Arrestin2 mediates the initiation and progression of myeloid leukemia.

Proceedings of the National Academy of Sciences of the United States of America - 31 Jul 2012

Fereshteh Mark, Ito Takahiro, Kovacs Jeffrey J, Zhao Chen, Kwon Hyog Young, Tornini Valerie, Konuma Takaaki, Chen Minyong, Lefkowitz Robert J, Reya Tannishtha

Abstract excerpt

β-Arrestins were initially discovered as negative regulators of G protein-coupled receptor signaling. Although β-arrestins have more recently been implicated as scaffold proteins that interact with various mitogenic and developmental signals, the genetic role of β-arrestins in driving oncogenesis is not known. Here we have investigated the role of β-arrestin in hematologic malignancies and have found that...

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Identifiers

PMID: 22773819
DOI: 10.1073/pnas.1209815109
PMCID: PMC3411976

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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