Targeted Disruption of β-Arrestin 2-Mediated Signaling Pathways by Aptamer Chimeras Leads to Inhibition of Leukemic Cell Growth

Abstract excerpt

UNLABELLED: β-arrestins, ubiquitous cellular scaffolding proteins that act as signaling mediators of numerous critical cellular pathways, are attractive therapeutic targets because they promote tumorigenesis in several tumor models. However, targeting scaffolding proteins with traditional small molecule drugs has been challenging. Inhibition of β-arrestin 2 with a novel aptamer impedes multiple oncogenic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer, Stress, Anesthesia, and Immune Response
• Share to Protein Degradation and Inhibitors
• Share to Receptor Mechanisms and Signaling