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Drug resistance is dramatically restored by hedgehog inhibitors in CD34<sup>+</sup> leukemic cells

24 Feb 2009

Abstract excerpt

Aberrant reactivation of hedgehog (Hh) signaling has been described in a wide variety of human cancers and in cancer stem cells. However, the contribution of Hh signaling to leukemic cell regulation has remained unclear. In this study, we assessed the possibility that Hh pathway activation contributes to the survival and drug resistance of cluster of differentiation (CD)34+ leukemia cells. Hh signaling in...

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PMID: 19245435
DOI: 10.1111/j.1349-7006.2009.01111.x

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