Article
CYP2D6 polymorphism and the presence of anti-LKM-1 in patients with chronic hepatitis C.
Biochemical and biophysical research communications - 21 Apr 2000
Hijikata M, Miyakawa H, Matsushita M, Kako M, Ohta Y, Mishiro S
Abstract excerpt
Anti-LKM-1 autoantibodies are directed mostly at cytochrome P450 2D6 (CYP2D6) autoantigen, whose activity ranges from "complete deficiency" to "extensive metabolism" due to genetic polymorphism. We aimed to find any relevance of CYP2D6 alleles to the presence/absence of anti-LKM-1 in Japanese patients with chronic hepatitis C. The frequency of an extensive metabolizer-type allele (CYP2D6*1) in anti-LKM-1-positive...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.