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Article

Efavirenz induced acute liver failure requiring liver transplantation in a slow drug metaboliser.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Sept 2013

Elsharkawy Ahmed M, Schwab Ulrich, McCarron Brendan, Burt Alastair D, Daly Ann K, Hudson Mark, Masson Steven

Abstract excerpt

Highly active antiretroviral therapy has revolutionised HIV management. However, many of these drugs are potentially hepatotoxic. Here, we report the first adult case of efavirenz induced acute liver failure successfully treated by liver transplantation. Furthermore, genetic analysis revealed our patient to be a slow efavirenz metaboliser, contributing to the severity of clinical presentation.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23763943
DOI: 10.1016/j.jcv.2013.05.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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