Article
In silico identification of microRNAs predicted to regulate the drug metabolizing cytochrome P450 genes.
Drug metabolism letters - 1 Apr 2011
Ramamoorthy Anuradha, Skaar Todd C
Abstract excerpt
OBJECTIVE: Cytochrome P450 (CYP) enzymes exhibit high interindividual variability that is not completely explained by known environmental and genetic factors. To further understand this variability, we hypothesized that microRNAs (miRNAs) may regulate CYP expression. METHODS: MiRNA identification algorithms were used to identify the miRNAs that are predicted to regulate twelve major drug metabolizing CYPs and to...
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