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Article

A dual inhibition: microRNA-552 suppresses both transcription and translation of cytochrome P450 2E1.

Biochimica et biophysica acta - 1 Apr 2016

Miao Lingling, Yao Hailan, Li Chenggang, Pu Mengfan, Yao Xuan, Yang Hui, Qi Xinming, Ren Jin, Wang Yizheng

Abstract excerpt

MicroRNAs (miRNAs) can direct post-transcriptional or transcriptional gene silencing. Here, we report that miR-552 is in the nucleus and cytosol and inhibits human cytochrome P450 (CYP) 2E1 expression at both transcriptional and post-transcriptional levels. MiR-552 via its non-seed sequence forms hybrids with a loop hairpin of the cruciform structure in CYP2E1 promoter region to inhibit SMARCE1 and RNA polymerase...

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Topics

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Share to Chromosomal Proteins, Non-Histone
Share to Cytochrome P-450 CYP2E1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Gene Silencing

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Share to Protein Biosynthesis

Share to RNA Polymerase II

Share to Transcription, Genetic

Source

Identifiers

PMID: 26926595
DOI: 10.1016/j.bbagrm.2016.02.016

Genes

SMARCE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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