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Article

Gene expression profiles in Parkinson disease prefrontal cortex implicate FOXO1 and genes under its transcriptional regulation.

PLoS genetics - 1 Jun 2012

Dumitriu Alexandra, Latourelle Jeanne C, Hadzi Tiffany C, Pankratz Nathan, Garza Dan, Miller John P, Vance Jeffery M, Foroud Tatiana, Beach Thomas G, Myers Richard H

Abstract excerpt

Parkinson disease (PD) is a complex neurodegenerative disorder with largely unknown genetic mechanisms. While the degeneration of dopaminergic neurons in PD mainly takes place in the substantia nigra pars compacta (SN) region, other brain areas, including the prefrontal cortex, develop Lewy bodie...

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Source

Open in PubMed Open full text

Identifiers

PMID: 22761592
DOI: 10.1371/journal.pgen.1002794
PMCID: PMC3386245

Genes

FOXO1
GAK
SMOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22761592-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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