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Article

Duplicated zebrafish co-orthologs of parathyroid hormone-related peptide (PTHrP, Pthlh) play different roles in craniofacial skeletogenesis.

The Journal of endocrinology - 1 Sept 2012

Yan Yi-Lin, Bhattacharya Poulomi, He Xin Jun, Ponugoti Bhaskar, Marquardt Ben, Layman Jason, Grunloh Melissa, Postlethwait John H, Rubin David A

Abstract excerpt

In mammals, parathyroid hormone-related peptide (PTHrP, alias PTH-like hormone (Pthlh)) acts as a paracrine hormone that regulates the patterning of cartilage, bone, teeth, pancreas, and thymus. Beyond mammals, however, little is known about the molecular genetic mechanisms by which Pthlh regulates early development. To evaluate conserved pathways of craniofacial skeletogenesis, we isolated two Pthlh co-orthologs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22761277
DOI: 10.1530/JOE-12-0110
PMCID: PMC3718479

Genes

PTH

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