Article
Identification of a potential physiological precursor of aberrant cells in refractory coeliac disease type II.
Gut - 1 Apr 2013
Schmitz Frederike, Tjon Jennifer M L, Lai Yuching, Thompson Allan, Kooy-Winkelaar Yvonne, Lemmers Richard J L F, Verspaget Hein W, Mearin M Luisa, Staal Frank J, Schreurs Marco W, Cupedo Tom, Langerak Anton W, Mulder Chris J, van Bergen Jeroen, Koning Frits
Abstract excerpt
OBJECTIVE: Refractory coeliac disease type II (RCDII) is a severe complication of coeliac disease (CD) characterised by aberrant intraepithelial lymphocytes (IELs) of unknown origin that display an atypical CD3(-)CD7(+)icCD3(+) phenotype. In approximately 40% of patients with RCDII these lymphocytes develop into an invasive lymphoma. In the current study we aimed to identify the physiological counterpart of these...
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