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<i>BRG1</i> and <i>NRG1</i> form a novel feedback circuit regulating <i>Candida albicans</i> hypha formation and virulence

3 Jul 2012

Abstract excerpt

In the opportunistic fungal pathogen Candida albicans both cellular morphology and the capacity to cause disease are regulated by the transcriptional repressor Nrg1p. One of the genes repressed by Nrg1p is BRG1, which encodes a putative GATA family transcription factor. Deletion of both copies of this gene prevents hypha formation. We discovered that BRG1 overexpression is sufficient to overcome Nrg1p-mediated...

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PMID: 22757963
DOI: 10.1111/j.1365-2958.2012.08127.x

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