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Article

Discrimination of single nucleotide mutation by using a new class of immobilized shared-stem double-stranded DNA probes.

Journal of biomedical nanotechnology - 1 Oct 2011

Bai Yunfei, Lin Dai, Han Qin, Jia Yaojuan, Tu Jing, Luo Junfeng, Ge Qinyu, Zhang Dingdong, Lu Zuhong

Abstract excerpt

An improved technique for single nucleotide mismatch discrimination using immobilized double-stranded DNA probes with a shared-stem hairpin (SH) structure is developed. A hairpin-like double-stranded DNA probe without any chromophore was immobilized on an agarose film-coated slide. The base number of the stem area was increased to 9-19 nt and the entire shared-stem area was included in the hybridization area, in...

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Identifiers

PMID: 22195481
DOI: 10.1166/jbn.2011.1327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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