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Article

Impact of genetic factors on platinum-induced gastrointestinal toxicity.

Mutation research. Reviews in mutation research - 1 Jan 2000

Zheng Yi, Deng Zheng, Tang Mimi, Xiao Di, Cai Pei

Abstract excerpt

Severe gastrointestinal (GI) toxicity is a common side effect after platinum-based chemotherapy. The incidence and severity of GI toxicity vary among patients with the same chemotherapy. Genetic factors involved in platinum transport, metabolism, detoxification, DNA repair, cell cycle control, and apoptosis pathways may account for the interindividual difference in GI toxicity. The influence of gene polymorphisms...

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Identifiers

PMID: 33339576
DOI: 10.1016/j.mrrev.2020.108324

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