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Article

Proper macrophagic differentiation requires both autophagy and caspase activation

2 Jul 2012

Abstract excerpt

Autophagy allows the elimination of superfluous or damaged macromolecules or organelles. Genetic evidence indicates that autophagy plays essential functions during differentiation. The differentiation of human blood monocytes into macrophages is a caspase-dependent process triggered by colony stimulating factor1 (CSF1/CSF-1). We have established, using pharmacological inhibitors, siRNA approaches and Atg7 (-/-)...

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Identifiers

PMID: 22751215
DOI: 10.4161/auto.20367

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