Why has butyrylcholinesterase been retained? Structural and functional diversification in a duplicated gene.

doi:10.1016/j.neuint.2012.06.016

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Article

Why has butyrylcholinesterase been retained? Structural and functional diversification in a duplicated gene.

Neurochemistry international - 1 Oct 2012

Johnson Glynis, Moore Samuel W

Abstract excerpt

While acetylcholinesterase (EC 3.1.1.7) has a clearly defined role in neurotransmission, the functions of its sister enzyme butyrylcholinesterase (EC 3.1.1.8) are more obscure. Numerous mutations, many inactivating, are observed in the human butyrylcholinesterase gene, and the butyrylcholinesterase knockout mouse has an essentially normal phenotype, suggesting that the enzyme may be redundant. Yet the gene has...

Topics

Acetylcholinesterase
Animals
Butyrylcholinesterase
Catalytic Domain
Genes, Duplicate
Humans
Mutation
Structure-Activity Relationship

Source

Open in PubMed

Identifiers

PMID: 22750491
DOI: 10.1016/j.neuint.2012.06.016

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