Article
Conformational dynamics of yeast calmodulin in the Ca(2+)-bound state probed using NMR relaxation dispersion.
FEBS letters - 30 Jul 2012
Ogura Kenji, Okamura Hideyasu, Katahira Masato, Katoh Etsuko, Inagaki Fuyuhiko
Abstract excerpt
Most calmodulin (CaM) in apo and Ca(2+)-bound states show a dumb-bell-like structure, involving the N- and C-terminal domains, connected with a flexible linker. However, Ca(2+)-bound yeast calmodulin (yCaM) takes on a unique globular structure; the target-binding site of this protein is autoinhibited. We applied NMR relaxation dispersion experiments to yCaM in the Ca(2+)-bound state. The amide (15)N and (1)H(N)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.