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Article

Molecular dynamics study of MspA arginine mutants predicts slow DNA translocations and ion current blockades indicative of DNA sequence.

ACS nano - 28 Aug 2012

Bhattacharya Swati, Derrington Ian M, Pavlenok Mikhail, Niederweis Michael, Gundlach Jens H, Aksimentiev Aleksei

Abstract excerpt

The protein nanopore Mycobacteria smegmatis porin A (MspA), can be used to sense individual nucleotides within DNA, potentially enabling a technique known as nanopore sequencing. In this technique, single-stranded DNA electrophoretically moves through the nanopore and results in an ionic current that is nucleotide-specific. However, with a high transport velocity of the DNA within the nanopore, the ionic current...

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Identifiers

PMID: 22747101
DOI: 10.1021/nn3019943
PMCID: PMC3448955

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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