Article
Nucleotide discrimination with DNA immobilized in the MspA nanopore.
PloS one - 1 Jan 2011
Manrao Elizabeth A, Derrington Ian M, Pavlenok Mikhail, Niederweis Michael, Gundlach Jens H
Abstract excerpt
Nanopore sequencing has the potential to become a fast and low-cost DNA sequencing platform. An ionic current passing through a small pore would directly map the sequence of single stranded DNA (ssDNA) driven through the constriction. The pore protein, MspA, derived from Mycobacterium smegmatis, has a short and narrow channel constriction ideally suited for nanopore sequencing. To study MspA's ability to resolve...
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