Article
Molecular variation at the SLC6A3 locus predicts lifetime risk of PTSD in the Detroit Neighborhood Health Study.
PloS one - 1 Jan 2012
Chang Shun-Chiao, Koenen Karestan C, Galea Sandro, Aiello Allison E, Soliven Richelo, Wildman Derek E, Uddin Monica
Abstract excerpt
Recent work suggests that the 9-repeat (9R) allele located in the 3'UTR VNTR of the SLC6A3 gene increases risk of posttraumatic stress disorder (PTSD). However, no study reporting this association to date has been based on population-based samples. Furthermore, no study of which we are aware has assessed the joint action of genetic and DNA methylation variation at SLC6A3 on risk of PTSD. In this study, we...
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