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Article

Hyperammonaemia induces mitochondrial dysfunction and neuronal cell death

23 May 2022

Abstract excerpt

Background & Aims In cirrhosis, astrocytic swelling is believed to be the principal mechanism of ammonia neurotoxicity leading to hepatic encephalopathy (HE). The role of neuronal dysfunction in HE is not clear. We aimed to explore the impact of hyperammonaemia on mitochondrial function in primary co-cultures of neurons and astrocytes and in acute brain slices of cirrhotic rats using live cell imaging. Methods To...

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PMID: 35845295
DOI: 10.1016/j.jhepr.2022.100510

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