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Article

Semliki Forest virus A7(74) transduces hippocampal neurons and glial cells in a temperature-dependent dual manner.

Journal of neurovirology - 1 Feb 2003

Ehrengruber Markus U, Renggli Martin, Raineteau Olivier, Hennou Sonia, Vähä-Koskela Markus J V, Hinkkanen Ari E, Lundstrom Kenneth

Abstract excerpt

In central nervous system (CNS) tissue preparations, wild-type Semliki Forest virus (SFV) mainly infects neurons, and in vivo it causes lethal encephalitis in neonatal and adult rodents. The SFV strain A7(74), by contrast, is avirulent in adult rodents, triggering only limited CNS infection. To examine A7(74) infection in hippocampal tissue, the authors constructed a replicon, termed SFV(A774nsP)-GFP, expressing...

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PMID: 12587065
DOI: 10.1080/13550280390173346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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