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Article

Screening for mutation R882 in the DNMT3A gene in Chinese patients with hematological disease.

International journal of hematology - 1 Aug 2012

Li Yunlong, Zhang Deng-Feng, Zhang Shi-Wen, Zeng Yun, Yao Yong-Gang

Abstract excerpt

The DNA (cytosine-5-)-methyltransferase 3 alpha (DNMT3A) gene is actively involved in epigenetic regulation. Mutations in this gene affect disease progression and response to therapy, particularly in hematological disease. Recent studies have demonstrated that DNMT3A gene mutations affecting codon R882 are actively involved in acute myelogenous leukemia (AML), and cause abnormal alteration of DNA methylation and...

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PMID: 22744846
DOI: 10.1007/s12185-012-1104-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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