Cytomorphological features of ALK-positive lung adenocarcinomas: psammoma bodies and signet ring cells.

doi:10.1002/cncy.21507

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Article

Cytomorphological features of ALK-positive lung adenocarcinomas: psammoma bodies and signet ring cells.

Cancer cytopathology - 1 Mar 2015

Pareja Fresia, Crapanzano John P, Mansukhani Mahesh M, Bulman William A, Saqi Anjali

Abstract excerpt

BACKGROUND: Correlation between histology and genotype has been described in lung adenocarcinomas. For example, studies have demonstrated that adenocarcinomas with an anaplastic lymphoma kinase (ALK) gene rearrangement may have mucinous features. The objective of the current study was to determine whether a similar association can be identified in cytological specimens. METHODS: A retrospective search for...

Topics

Adenocarcinoma
Adenocarcinoma, Mucinous
Adult
Aged
Aged, 80 and over
Anaplastic Lymphoma Kinase
Animals
Carcinoma, Papillary
Carcinoma, Signet Ring Cell
Female
Follow-Up Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Rearrangement

Humans

Lung Neoplasms

Male

Middle Aged

Mutation

Neoplasm Staging

Source

Open in PubMed

Identifiers

PMID: 25557162
DOI: 10.1002/cncy.21507

Genes

ALK
EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-25557162-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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