Article
Cytomorphological identification of advanced pulmonary adenocarcinoma harboring KRAS mutation in lymph node fine-needle aspiration specimens: Comparative investigation of adenocarcinoma with KRAS and EGFR mutations.
Diagnostic cytopathology - 1 Jul 2015
Song Dae Hyun, Lee Boram, Shin Yooju, Choi In Ho, Ha Sang Yun, Lee Jae Jun, Hong Min Eui, Choi Yoon-La, Han Joungho, Um Sang-Won
Abstract excerpt
BACKGROUND: Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) mutation in pulmonary adenocarcinoma is clinically important due to its association with resistance to EGFR inhibitors and poor prognosis. To our knowledge, there has not been a comparative study focusing on cytological nuclear features of pulmonary adenocarcinoma harboring KRAS mutation (KRAS-AD). Hence, we compared the cytomorphology of metastatic...
Topics
- Adenocarcinoma
- Aged
- Biomarkers, Tumor
- Biopsy, Fine-Needle
- ErbB Receptors
- Female
- Gene Expression
- Humans
- Immunohistochemistry
- Lung Neoplasms
- Lymph Nodes
- Lymphatic Metastasis
- Male