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Article

Chemical rescue of the distal histidine mutants of tryptophan 2,3-dioxygenase.

Journal of the American Chemical Society - 25 Jul 2012

Geng Jiafeng, Dornevil Kednerlin, Liu Aimin

Abstract excerpt

Tryptophan 2,3-dioxygenase (TDO) is a heme-dependent enzyme that catalyzes the oxidative degradation of L-tryptophan (L-Trp) to N-formylkynurenine (NFK). A highly conserved histidine residue in the distal heme pocket has attracted great attention in the mechanistic studies of TDO. However, a consensus has not been reached regarding whether and how this distal histidine plays a catalytic role after substrate...

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Identifiers

PMID: 22742206
DOI: 10.1021/ja304164b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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