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Article

Structure and activity of the only human RNase T2.

Nucleic acids research - 1 Sept 2012

Thorn Andrea, Steinfeld Robert, Ziegenbein Marc, Grapp Marcel, Hsiao He-Hsuan, Urlaub Henning, Sheldrick George M, Gärtner Jutta, Krätzner Ralph

Abstract excerpt

Mutations in the gene of human RNase T2 are associated with white matter disease of the human brain. Although brain abnormalities (bilateral temporal lobe cysts and multifocal white matter lesions) and clinical symptoms (psychomotor impairments, spasticity and epilepsy) are well characterized, the pathomechanism of RNase T2 deficiency remains unclear. RNase T2 is the only member of the Rh/T2/S family of acidic...

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Identifiers

PMID: 22735700
DOI: 10.1093/nar/gks614
PMCID: PMC3458558

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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