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Article

The role of genetic and epigenetic GNAS alterations in the development of early-onset obesity.

Mutation research. Reviews in mutation research - 1 Jan 2000

Abbas Alaa, Hammad Ayat S, Al-Shafai Mashael

Abstract excerpt

BACKGROUND: GNAS (guanine nucleotide-binding protein, alpha stimulating) is an imprinted gene that encodes Gsα, the α subunit of the heterotrimeric stimulatory G protein. This subunit mediates the signalling of a diverse array of G protein-coupled receptors (GPCRs), including the melanocortin 4 receptor (MC4R) that serves a pivotal role in regulating food intake, energy homoeostasis, and body weight. Genetic or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Melanocortin, Type 4

Source

Identifiers

PMID: 38103632
DOI: 10.1016/j.mrrev.2023.108487

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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