Article
Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation.
Cell metabolism - 1 Jun 2009
Chen Min, Wang Jie, Dickerson Kathryn E, Kelleher James, Xie Tao, Gupta Divakar, Lai Edwin W, Pacak Karel, Gavrilova Oksana, Weinstein Lee S
Abstract excerpt
In Albright hereditary osteodystrophy, a monogenic obesity disorder linked to heterozygous mutations of G(s)alpha, the G protein that mediates receptor-stimulated cAMP generation, obesity develops only when the mutation is on the maternal allele. Likewise, mice with maternal (but not paternal) ge...
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