Article
G(s)alpha deficiency in adipose tissue leads to a lean phenotype with divergent effects on cold tolerance and diet-induced thermogenesis.
Cell metabolism - 7 Apr 2010
Chen Min, Chen Hui, Nguyen Annie, Gupta Divakar, Wang Jie, Lai Edwin W, Pacak Karel, Gavrilova Oksana, Quon Michael J, Weinstein Lee S
Abstract excerpt
G(s)alpha, the G protein that mediates receptor-stimulated cAMP generation, has been implicated as a regulator of adipogenesis and adipose tissue function. Heterozygous G(s)alpha mutations lead to obesity in Albright hereditary osteodystrophy (AHO) patients and in mice. In this study, we generated mice with adipose-specific G(s)alpha deficiency. Heterozygotes had 50% loss of G(s)alpha expression in adipose tissue...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.